I was motivated by a web apps presentation by Seth Ladd, a Google Chrome developer advocate, to write a short white paper why my organization should be moving in this direction. But it's hard to get around the fact that native apps still beat the pants off of web apps in many functional areas. Until this week, I wasn't aware Google was working on Native Client, a way to run native compiled code directly in the browser. This certainly makes sense if Chrome is to become a major OS.
I don't think I'm brave enough to fool around with the developer release SDK right now - I'm busy working on my Android app - but once it goes beta it'll be worth a look.